Autocrine and paracrine signals are of paramount importance in both normal and oncogenic events and the composition of such secreted molecular signals (i.e the secretome) designate the communication status of cells.In this context, the analysis of post-translational modifications in secreted proteins may unravel biological circuits regulated by irr
Abstract Despite advances in treatment regimens that comprise surgery, chemotherapy, and radiation, outcome of many brain tumors remains dismal, more so when they recur.The proximity of brain tumors to delicate neural structures often precludes complete surgical resection.Toxicity and long-term side effects of systemic therapy remain a concern.Nove
The United States and the Canadian province of Ontario have enacted endangered species laws that regulate private land.The rationale for this is that the vast majority of endangered species in the two countries rely on private lands for survival.However, from a landowner perspective the law is deemed unfair.This paper presents analysis from 141 int
A 44-year-old woman visited a hospital with microscopic hematuria Slippers in June 2009.Computed tomography showed a large bladder diverticulum at right lateral wall and urachal remnant.Cystoscopic examination showed a large diverticulum at the right lateral wall that closes to the dome.She was followed up closely without therapeutic intervention;
Since the industrial revolution of XVIII century knowledge begins to be appreciated mainly for its practical utility.Technological model of knowledge becomes dominant in natural sciences and extends to humanities.Supporters of naturalistic position insist that our knowledge about people and society should lead to enhanced management practices.The a